Abstract:
This is a cross-sectional descriptive and analytical study, conducted at Sudan Heart
Center during the period of February to June 2011. The aim of this study was to
assess the haemostatic parameters(Prothrombin time(PT), International normalized
ratio(INR) and Activated partial thromboplastine time (A PTT) ) in Oral anti
coagulated (warfare )people who attended Heart Center, One hundred warfarin
administrated patients as study group, and twenty five (25) of healthy
warfarin administrated
non
(control), The participants were informed about the study
and agreed for participation. The study population was divided into four groups
according to type of disease: RV +Repair, DVT, PE, AF. 1.8 ml of venous blood
drained into 0.2 tri-sodium citrate container from each subject, these were tested
for PT, INR and APTT level. Fully automated hematological analyzer (sysmex
CA500) was used for analyzed PT, INR, APTT, and Statistical analysis showed
significant increase in PT mean (13.09sec), INR mean (1.11), and PTT mean
(31.38sec) in non
warfarin
administrated
administrate patient PT(35.90sec),
in comparesion
with warfarin
INR (2.95), PTT (35.13sec)were P.value
(0.000) (0.005) (0.000) respectively. There insignificant (P.value 0.43) was noted
between the Age group (cases) in PT (sec) mean, and also was insignificant in PTT
(sec) mean P.value (0.29)
and insignificant in INR mean P. value (0.68). The
study was also showed that there was insignificant in warfarin dose (mg) group in
PT (sec) P.value (0.51), in INR P.value (0.58) and in PTT (sec) P .value
(0.34).The result was significant in INR range compared
with administrated
warfarin were in control INR value (1.0) and in cases (2.37) p. value (0.000)
and there was also significant between INR Range in cases(warfarin administrate )
and control (non warfarin administrate ) were
( 2—3) , (1—2 )respectively , P .value ( 0.000).
