Abstract:
This study was performed in Khartoum state during the period from
January to May 2011. The aim of the study is to compare the sensitivity
of C – reactive protein (CRP) and cholesterol as early marker of
cardiovascular diseases in Sudanese smokers.
75 blood samples were collected from Sudanese smokers and 75 healthy
non smokers as a control group for the comparison. The test and control
groups were ages matches and range from18to 60years. Serum
cholesterol was estimated by spectrophotometer (Biosystem 310), and
CRP level was estimated by automation technique (Mindary BS 300).
There was a significant increase in both the C-reactive protein level and
cholesterol level in the test group of smokers when compared with non
smokers (4.26±.84mg/L versus 1.75±.37mg/L), (P=0.000), and
(185±41mg/dL versus 163±23mg/dL) respectively(P = 0.000). According
to the duration of cigarettes smoking the study observed significant
increase in the mean of CRP level in the three groups of smokers when
compared with control group, (6.26±.91mg/L, p=.023; 3.57±.48mg/L,
p=.004; 3.62±.43mg/L, P=.011) respectively. Whereas there is no
significant difference in cholesterol level in group(1) ≤5 when compared
with non smokers group (p=.118). The study record a significant increase in cholesterol level in group(2) 6-15 and (3) >15 when compared with
)300.=non smokers group, (182±43mg/dL) (p=.012), (196±42mg/dL) ( p
respectively. Also with number of cigarettes smoked per day the study
-11 )2( observed a significant increase in CRP level in group(1)≤10 and
02
,)900.=when compared to non smokers, (4.46±.85mg/L) (p
(4.19±.82mg/L) (p=.002) respectively, but there is insignificant increase
in group(3) >20 when compared to non smokers(p=.070). Whereas
cholesterol level show significant increase in the three groups of smokers
)000.=(185±39mg/dL, p=.004; 185±41mg/dL, p=.010; 18 ±50mg/dL, p
respectively. The study recorded no significant correlation between CRP
with both the duration of cigarettes smoking per year and number per day
.( p=.101, .447) respectively
In conclusion: The study revealed that C – reactive protein level increase
in short period of smoking, in contrast cholesterol level increase in a long
.period of smoking
