Detection of Androgen Receptor among Sudanese Patients with Prostate Lesions

Abstract

This is a hospital based descriptive retrospective study conducted at Omdurman Military Hospital (Khartoum state) during the period from March to July 2013, aimed to detect androgen receptor in prostate cancer. A total of 40 patients previously diagnosed with prostatic lesions were selected in this study. Their ages ranged between 50-88 years old with mean age (66) year. Tissue sections were stained using two methods; histochemical method using histopathological method using haematoxylin diagnosis new indirect and and eosin stain for immunohistochemical technique for androgen receptor. The data obtained was analyzed using SPSS program version 11.5. Out of 40 patients with prostatic lesions, histopathological diagnosis revealed 13(32.5%) as prostatic hyperplasia and 27 (67.5%) as adenocarcinoma. Adenocarcinoma showed 10 (37%) well differentiated, 13(48%) moderate differentiated and 4 (15%) poor differentiated. Depending on histopathological diagnosis as gold standard the expressions of AR were found as 2 and 14 in benign hyperplasia and adenocarcinoma lesions respectively, with significant relation between AR expression and type of lesions. This study found no significant relation between AR expression and age group. High expression common among well differentiated adenocarcinoma while moderate and poor differentiated show commonly negative results with insignificant relation between AR expression and cancer stages. The study conclude AR expression help in differentiation between benign hyperplasia and adenocarcinoma.