Abstract:
This is descriptive analytical study carried out in Khartoum state in Turkish hospital,
and laboratory administration, in the period from (March 2011 to August 2011) to
evaluate some coagulation tests among Sudanese Hypertensive patients in Khartoum
State. Hundred diagnosed hypertensive patients were selected 42(42%) male and
58(58%) female and fifty healthy individuals were selected as control group. 4.5ml of
venous blood was with drown from each patient, placed in tri sodium citrate container,
then centrifuge to get platelets poor plasma (ppp) and that is to assess PT, APTT,
fibrinogen and D-dimer. The results were analyzed by use SPSS version11.5, and
express as means. The results obtained from patients that the means of
PT( Prothrombin time), APTT (Activated partial thromboplastin time), fibrinogen and
D-dimer in patients group. The mean of PT, APTT, fibrinogen and D-dimer in control
group, (13 sec), (30.6 sec), (221 mg/dL) and (0.14 mg/L) respectively. The results
showed no significant differences between the mean of patients and controls in the
Prothrombin time (PT) (p value >0.005) and Activated Partial Thromboplastin Time
(APTT) in both sex (p value >0.005) while results demonstrated a significant
differences between the mean of patients and controls in Fibrinogen level and D-dimer
in both sex (p value <0.005).
The results obtained indicated that measurement of Prothrombin time (PT) and
Activated partial thromboplastin (APTT) were unnecessary when evaluating
hypertensive patients whom there was clinical evidence of hemostatic abnormality.
The results of this study raised the possibility of that fibrinogen level and D-dimer
could be use in identifying risk group of hypertensive patients who were likely to
develop thrombotic events.
