Abstract:
The aim of this study was to assess correlations between the serum levels of
urate, lipid profile (total cholesterol, LDL- cholesterol, HDL- cholesterol and
triglycerides) to Hemoglobin A1c% among Sudanese with type 2 diabetic patients
and to compare these variables with apparently healthy individuals as a control
group. A case-control study was conducted during the period from January 2011 to
November 2012 in Khartoum state among 150 Sudanese diabetic patients and 100
healthy controls for comparison. The serum levels of lipid profiles and serum urate
were measured using chemistry analyzer (BS-200) and commercial kits from
Biosystem company, Hemoglobin A1c% analyses was performed using Nycocard
reader II and commercial kits from Nycocard company, LDL-C was calculated
using Friedewald`s Formula.
The results of this study showed the means of the serum levels of total
cholesterol, LDL-C, triglycerides and urate of the diabetic group were significantly
raised when compared to the control group, whereas the means of the serum levels
of HDL-C of the diabetic group were significantly reduced when compared to the
control group. The study showed weak positive correlation between the glycated
hemoglobin and total cholesterol (r=0.20), LDL-C (r=0.36) and serum urate of
diabetic group (r=0.28) and very weak positive correlation with triglycerides
(r=0.10) and also showed weak negative correlation between glycated hemoglobin
and HDL-C in the diabetic group (r=0.32). From this study it is concluded that the
serum levels of total cholesterol, triglycerides, LDL-C and serum urate are
significantly raised, whereas the serum levels of HDL-C were significantly reduced
in Sudanese patients with type 2 Diabetes mellitus. HbA1c% has a significant weak
positive correlation with the serum levels of T. cholesterol, LDL and urate and has
insignificant correlation with the serum levels of triglycerides and a significant
negative correlation with the serum level of HDL-C. The results of this study,
suggest a relationship between insulin resistance, glycaemic control and the
metabolism of lipids and urate.
