Evaluation of the Plasma Levels of Total Protein, Albumin and the Activity of Alanine and Aspartate Transaminases in Sudanese Patients with Schistosomiasis

Abstract

A cross sectional study conducted during the period from May to July 2012 to evaluate plasma alanine aminotransferase (ALT), aspartate aminotransferase (AST), total protein and albumin levels in schistosomiasis patients.(70)Sudanese with schistosomiasis were selected as a test group from Al Kemair village (river Nile state) and Omma hani village (white Nile state), Sudan. The test group was compared with a control group which included (50) healthy volunteers. Blood specimens were collected from both groups using lithium heparin anticoagulant and plasma levels ALT and AST, total protein and albumin were determined using enzymatic methods by using Biosystem and Crescent diagnostics commercial kits and by using spectrophotometer . Statistical Package for Social Science (SPSS) version11.5 computer software was used for data analysis. Results of this study indicated there is insignificant difference between the mean plasma level of ALT, AST and total protein between the test group and control group, there were no difference between the two groups. Plasma level of albumin is significantly decreased after infection of schistosomiasis, and there were significant weak negative correlation between plasma levels of AST and duration of disease, also there is significant weak positive correlation between plasma levels of ALT, total protein and albumin and duration of disease. In conclusion the present results of this study indicated that the age group of less than 30 years the most affected by schistosomiasis and male affected by schistosomiasis more than female.