Assessment of Serum Levels of Thyrotropin and Thyroxine among Sudanese Patients with Type2 Diabetes Mellitus

Abstract

A case control study was conducted during the period from April to October 2012 to assess serum levels of thyrotropin(TSH) and thyroxineT4 among sudanese patients with type2 diabetes mellitus. Fifty patients with type2 diabetes mellitus were selected as a test group from the Khartoum Teaching Hospital and Zenam Hospital in Khartoum state ,Sudan. The test group was compared with a control group which included 40 apparently healthy volunteers. Blood specimens were collected from both groups and fasting blood glucose, glycated hemoglobin, thyrotropin and thyroxine were estimated. Age and gender of the test group were matched with the control group. Spectrophotometeric methods were used for measurement of glucose. Glycated hemoglobin was measured by using chromatographic- spectrophotometric ionexchange method and the thyrotropin and thyroxine measured by Electrochemiluminescent method. Statistical package for social science (SPSS version 11.5) computer software was used for data analysis. The results of this study indicated a significant decrease in the mean of serum levels of thyroxine in test group compared with the control subjects and insignificant deference in the mean of serum levels of thyrotropin. Also there was insignificant deference in the mean of serum levels of ‫‪thyrotropin and thyroxine in diabetic males compared to diabetic‬‬ ‫2‪females. There was no correlation between thyrotropin in type‬‬ ‫‪diabetic patient and fasting blood glucose, glycated hemoglobin and‬‬ ‫‪body mass index. Also there was negative correlation between‬‬ ‫‪thyroxine in type2 diabetic patient and fasting blood glucose; and no‬‬ ‫‪correlation between thyroxine in type2 diabetic patient and glycated‬‬ ‫.‪hemoglobin and body mass index‬‬