Abstract:
This study was conducted in the laboratory of
biochemistry of king Saud
University to test the
kinetic activity of butyrylcholinesterase enzyme
(BuchE) against nine antihistamine drugs . All the
drugs tested showed significant inhibition of the
enzyme.
However , some drugs show mixed type
inhibition while the others showed non-competitive
inhibition
. The former group include priactine ,
Fenistil , Actidil and Cetylepyridiniumchloride and
the second included Polaramine , Adol ,Cafemol ,
Histop and and Rihnoprot .
The
enzyme
butyrylcholinesterase
(BuchE)
helps in the degradation of excess drugs that get
to
the
body
to
facilitate
their
excretion
.
Unfortunately it was antihistamine drugs which
might pose a problem for some individuals.
