Abstract:
This is retrospective descriptive study, aimed to study the expression of
EBV among Sudanese patients with lymphoma cancer.
They were
conducted in Radiation and isotope center-Khartoum, during the period
from September 2011 to July 2012.
Fifty blocks were selected randomly from tissue block of patients with
lymphoma
cancer.
Tissue
section
was
stained
using
immunohistochemistry methods for detection of EBV marker (LMB-1).
The obtained data and results were analyzed using SPSS computer
program.
A total of 50 samples obtained from patients with lymphoma cancer
were
investigated
in
this
study
(33(66%)NHL-B
3(6%)NHL-T
14(28%)HL), their ages ranged between 5 to75 years with mean age of 40
years old.28(56%) patients were males and 22(44%) were females.
Twenty samples were positive expression for the demonstrated EBV
marker (LMB-1); 14(28%) out of them were Non-Hodgkin's lymphoma
B-cell and 6(12%) Hodgkin's lymphoma, consequently of 30 patients
negative expression EBV, 19(38%) were Non-Hodgkin's lymphoma-B
cell, 3(6%) Non-Hodgkin's lymphoma T-cell and 8(16%) Hodgkin's
lymphoma.
From the obtained results, the study concluded that, the expression of
EBV marker (LMP-1) among Sudanese patients was statistically
insignificant, although 20 samples positive for EBV
