Abstract:
This study was conducted during the period to
investigate the diagnostic value of cardiac creatine kinase
enzyme ( CK) and isoenzymecreatine kinase (CK-MB) as
myocardial markers has been assessed in this study using
spectrophotometer method. A study of 30 Sudanese
patient (16 male / 14 female ) admitted Sudan Center for
Heart during the period April- June 2012. The patient are
ofa average age “30-80” years. A group of 30 healthy
subjects match in age were enrolled as control group.
Blood samples were taken from all patients at first 24
hours to estimate the levels of CK enzyme and CK-MB by
using spectrophotometric method. A significant increased
of CK enzyme had been observed in MI patients (p<0.05),
the average concentration levels (257.97±138.754) when
compared to control subjects(74.97±22.785).but there
was no statisticaly difference
in CK-MB between patient
and healthy control group(p >0.05). but clinically CKMB
slight
elevated
in
patient
more
than
control
(39.17±11.164), (10.60±5.581) respectively. the mean
activities of both total CK and CKMB were not affected by
sex (p > 0.05). the majority of patients admitted CCU of
Sudan center of heart suffering from chest pain attack was
at advanced age (40-70) years and had mean activities of
total CK and CK-MB were higher than those of patients who
have an age less than 40 years.
In conclusion the study confirm that CK-MB is an
important
IV
diagnostic
marker
that
can
be
used
for
detection of myocardial infraction and follow up of
patients, particularly when such information cannot be
obtained following clinical and ECG examination.
