Abstract:
This is a hospital based, analytical, descriptive, cross
sectional and case control study was conducted in
Khartoum teaching hospital during period from 5 March
2012 to 22 June 2012, aimed to determine prothrombin
time (PT), international normalization ratio (INR), activated
partial thromboplastin time (APTT) and fibrinogen level
among
liver
disease
patients.
Blood
samples
were
collected from sixty patients with liver diseases(chronic
liver disease, hepatitis B and C viruses, cirrhosis, jaundice
and hepatocellular carcinoma) as case group and thirty
samples were collected from healthy individuals as control
group into citrate containers.
Citrate
blood
samples
were
centrifuged
to
harvest
platelets poor plasma for measurements of PT, INR, APTT
and fibrinogen level using sysmex CA500 coagulometer.
Data obtained were analyzed using Statistical Package of
Social Sciences (SPSS version 11.5).
The result revealed
that there was significant increase in PT, p. value (0.00),
INR p. value (0.00) , APTT p. value (0.00) and significant
decrease in fibrinogen level p. value (0.00) among
patients of liver diseases when compared with control
group. There were no any changes in PT, INR, APTT and
fibrinogen level related to age and gender.
The study concluded that
PT ,INR and APTT in patients
with liver diseases were increased and Fibrinogen level was
decreased in liver diseases compared to normal control.
