Abstract:
A case control study was conducted during the period from March
2012 to June 2012 to assess the plasma levels of high sensitive c-
reactive protein and cholesterol among Sudanese with type2 diabetes
mellitus. Hundred patients with type2 diabetes mellitus were selected
as a test group from the military hospital and Zenam diabetes center
in Khartoum state, Sudan.
The test group was compared with a control group which included 50
healthy volunteers. Blood specimens were collected from both groups
and fasting blood glucose, glycated hemoglobin, total cholesterol and
high sensitive c-reactive protein were estimated.
Age and gender of the test group were matched with the control
group. Spectrophotometeric methods were used for measurement of
glucose and total cholesterol. glycated hemoglobin was measured by
using NycoCard II device and the high sensitive c-reactive protein was
measured by using i-CHROMA device . Statistical package for social
science (SPSS version 11.5) computer software was used for data
analysis.
The results of this study indicates a significant increase in the mean of
the plasma levels of high sensitive c-reactive protein of the test group
when compared with the control group, and a significant elevation in
the mean of plasma levels of high sensitive c-reactive protein in
diabetic patients with hypertension when compared with the mean of
those without hypertension. Also there is a significant elevation of the
plasma levels of high sensitive c-reactive protein in females with
type2 diabetes mellitus when compared with the mean of diabetic
males.
The results of the current study indicates a significant, strong positive
correlation between high sensitive c-reactive protein in type2 diabetic
patients and fasting blood glucose, and there is a significant, strong positive correlation between high sensitive c-reactive protein in type2
diabetic patients and glycated hemoglobin.
Also indicates a significant, strong positive correlation between high
sensitive c-reactive protein in type2 diabetic patients and body mass
index and there is a significant, strong positive correlation between
high sensitive c-reactive protein in type2 diabetic patients and the
total cholesterol.
