Assessment of Complete Blood Count of Pregnant Women in Port Sudan City

Abstract

This is a cross-sectional case control descriptive analytical study, conducted at Port Sudan city during the period from April to July 2012. The aim of this study was to determine Hb, RBCs, HCT, MCV, MCH, MCHC, Platelets, WBCs, Leukocyte differential count, RDW, MPV of Sudanese pregnant women attending Sea Ports corporation Hospital and Port Sudan Teaching Hospital (Obstetric department). Eighty (80) healthy pregnant women were informed about the study and agreed for participation. A questionnaire was designed to collect information about the study group such as age, number of pregnancies, stage of trimesters, history of abortion and whether they visit the clinics regularly. Three ml of venous blood was collected in EDTA anticoagulant container. Automated hematological analyzer (Sysmex KXN-21) was used to measure Complete Blood Count. Leukocyte differential count was estimated manually. The results indicated that RBC (mean=4.2×106/μl ±0.7), Hematocrit (mean=34.1% ±4.0), and lymphocytes (mean=28.0% ±8.0) of pregnant women decreased significantly (p.value 0.00, 0.01, 0.00 respectively) while MCHC (mean=33.6g/dl ±1.4) increase significantly (p.value 0.03) compared to control. WBC (mean=7.3×103/μl ±2.0) and neutrophils (mean=64.0% ±8.4) increased significantly (p.value 0.00). Hemoglobin (mean=11.5g/dl ±1.3), platelets (mean=267.0×103/μl ±65.9), eosinophils (mean=3.0% ±2.0), basophils (mean=0.04% ±0.2) and MPV (mean=10.0fl ±1.0) decreased insignificantly (p.value ˃ 0.05) while MCV (mean=83.4fl±6.3), MCH (mean=28.1pg ±2.9) and RDW (mean=14.3% ±2.0) increased insignificantly (p.value > 0.05). Hemoglobin (mean=10.8g/dl ±1.0), MCV (mean=81.0fl ±6.0), MCH (mean=27.0pg ±3.0) and platelet (mean=236.6×103/μl±76.0) of pregnant women with previous pregnancies between 7 to 10 pregnancies insignificantly decreased (p.value >.0.05) compared to other groups. WBC (mean=8.0×103/μl±2.1) of pregnant women with number of pregnancy between (1-3) pregnancies increased insignificantly (p.value > 0.05) compared to those of pregnancy between (4-7) and (7-10). WBC (mean=8.0×103/μl ±2.1) of pregnant women at third trimester increased insignificantly (p.value 0.08) while lymphocytes (mean=25.0% ±7.0) decreased significantly (p.value 0.01) than those women at first and second trimesters. Neutrophils (mean=66.2% ±8.0) of women at third trimester increased significantly compared to those in first and second trimesters (p.value 0.02). when compared of different trimesters with control the result was WBCs and neutrophils increased significantly at third trimester (p.value 0.00) but 4 lymphocytes was decreased significantly at third trimester (p.value 0.00) MPV (mean=10.1fl ±1.0) of pregnant women with history of abortion significantly increased compared to those with no history of abortion (p.value 0.03). RBC (mean=4.2×106/μl±0.5) and HCT (mean=34.5%±3.6) of pregnant women increased significantly (p.value 0.01) with regularly visits to clinics (79%) while basophils (mean=0.0%±0.2) decreased insignificantly (p.value >0.05) compared to those with irregular visits clinics (21%)