Abstract:
Schistosoma mansoni infection in Sudan causes serious health problems
and economic consequences especially among schoolchildren, women of
reproductive age and the working group of agriculture-associated people
Praziquantel has been introduced as the drug of choice for control of
infection .
The aim of this study was to cast a light on the possible affect of
praziquantel and some genetic factor on regression of the grade of
Periportal fibrosis PPF 12 months after treatment of infected patients
with S.mansoni .
The study enrolled 100 Sudanese nationals diagnosed as schistosomiasis
patients in um-zukra with active S.mansoni infection complicated with
different grades of PPF were enrolled in the study. All the participants
underwent abdominal ultrasonography evaluating the grade of PPF and
given praziquantel as treatment according to appropriate dose for each
of them (40 mg/kg BW). They were further assessed by ultrasonography
12 months later.
The study found that, 46 (46%) grades of PPF regressed to the lower
grades of fibrosis, 34 (34%) remained stable and 20(20%) progressed to
the higher grades of fibrosis. Age and gender were significantly
associated with changes in grades of PPF. Regression of PPF among
females was more frequent than in males patients.
Three polymorphisms (IFN- rs2069705 (C/T), TGF-1+869 T/C and
ILB-1-31T/C that had screened to assess their role in regression or
progression of PPF after praziquantel therapy showed that there was no
significant association between this polymorphism and disease
prognosis (P.value :0.35) However TGF- 1 +869 T/C- T/T homozygous
and C/T heterozygous genotypes were more frequent in subjects with
low grade of fibrosis (72.7%, P.value :0.029) (F I)
Similarly (ILB-1 31 T/C) TT homozygous and CT heterozygous
genotypes were significantly more frequent in subjects with low grade of
fibrosis(P.value :0.0001). in conculation While polymorphism may not
contribute to PPF prognosis ,yet it could be a predisposing factor
