Evaluation of Plasma Urea and Plasma Creatinine Concentrations in Asthmatic Patients under Steroids Therapy in Alshaab hospital and Bahri Hospital

Abstract

Asthma is a chronic inflammatory disease of airways and it is a very common disease with immense social impact. The treatment of asthma affects the concentration of plasma urea and creatinine. This is descriptive analytical study conducted during the period from the February to July 2014to evaluate plasma concentration of urea and creatinine in asthmatic patients under steroid therapy, included 30 patients with hypertensive and non-hypertensive Asthmatic patients as case group, and 20 healthy individual as control group. Samples were collected to measure the concentration of urea and creatinine by using colorimetric methods. The data analyzed by SPSS program. The result found significant increase in the mean of creatinine between asthmatic patients and non-asthmatics (P-value = 0.001), and no significant difference between mean of urea in case and control (P-value = 0.06). Also there is no significant difference between mean of creatinine and urea in hypertensive and non-hypertensive asthmatic patients (P-value = 0.198, 0.797) respectively. This study shows that there is significant negative moderate correlation between creatinine and concentration treatment duration and insignificant weak negative correlation between urea and concentration treatment duration. The present study showed that the asthma treatment has effect on creatinine concentration with the duration of treatment resulting in lowering creatinine concentration, and no effect on urea concentration.