Abstract:
A prospective study conducted during the period April to
December 2004, compared serum level of the liver enzymes;
a spartate transaminase, alanine transaminase and alkaline poshatase
and serum levels of electrolytes (sodium and potassium) of 50
patients with diabetic ketoacidoisis, chosen randomly from
Omdurman, Albolek, Elno and Khartoum north teaching hospitals,
and 30 apparently, healthy individuals as controls.
The serum levels of aspartate transminase AST, alanine
transaminase (ALT) and potassium were all significantly raised
(p<0.001) in the diabetic ketoacidosis group. Mean ± SD for controls
versus diabetics.
(17.1 ±1.7 versus 42.5± 7.0 u/L) for AST
(14.5± 2 versus 37.8 ± 6.0 u/L) for ALT
(3.8 ± 0.5 versus 5.8 ± 0.6 mmol) for potassium.
The serum levels of sodium (Na+) were significantly reduced
in the diabetic ketoacidosis group. Mean ± SD for controls versus
diabetics.
(138.7 ± 5.1 versus 129.1± 4.8 mmol/L)
The serum levels of alkaline phosphatose (ALP) showed no
significant difference when the study group is compared with the
control group.
(7.7 ± 2.1 versus 8.6 ± 2.5 KA u/l) for ALP.
In the study group there were no significant difference
between those belong to type I diabetes (n=40) and these belong to
type II diabetes mellitus. (n=10) in serum levels of AST, ALT, ALP
and electrolytes Na+ and K+. (P>0.05).
It is concluded that; the levels of transminase (AST, ALT) and
potasium are significantly raised in patients with diabetic
ketoacidosis while the levels of sodium are significantly reduced but
those of Alkaline phosphatase are not affected.
