Assessment of Serum Anticardiolipin and Progesterone in Sudanese Women with Recurrent Miscarriage-Study in Khartoum State

Abstract

The objective of thisstudy was to assess serum anticardiolipin and serum progesterone in Sudanese women with recurrent miscarriage in comparison with apparently health women. A cross – sectional ,hospital based study was conducted during the period from March 2011 to April 2012 , in Khartoum state . 86 blood samples were collected from woman with recurrent miscarriage (case group), and 86 blood samples from woman with apparently healthy ( control group) ,age were matched in both groups . serum anticardiolipin and serum progesterone were measured using ELISA and commercial kits from EROIMMUNE and DRG Company . The results showed a significant increase in means serum anticardiolipin antibodies (ACL) in patient group (5.554± 3.421 ng/dL) when compared with the control group (1.197± 1.111 ng/dL) P value 0.000 .There were significant decrease in serum progesterone among patient group (4.419± 2.932ng/dL) when compared with the control group(32.01± 2.939ng\dL) P .value 0.000. There were significant increase in means serum anticardiolip in case group group (5.554± 3.421 ng/dl) when compared with both control groups, control pregnant group(1.23± 0.999 ng/dL) P .value 0.001, and control non pregnant group (1.161± 0.112 ng/dL) P value0.000. There were significant decrease in serum progesterone in the patient group (4.419± 2.932ng/dL) when compared with both controls , control pregnant group women (20.042± 17 ng/dL) P value 0.000,and control non pregnant group (8.06± 5.80ng\dL) P value0.000 .There was significant positive correlation between serum anticardiolipin and serum progesterone(r=0.245,p=0.02). There was insignificant positive correlation between the number of miscarriage and serum progesterone( r=0.122, p=0.2) ,also there was insignificant positive correlation between the serum anticardiolipin and the number of miscarriage(r=0.151, p=0.166 ) .Thefrequency of positive anticardiolipin among case group was 11.6 % while it was 1.2% among control group . Conclusion: There were significant increase in serum anticardiolipin ,and significant decrease in serum progesteroneof the case group when compared to the control group. There was significant positive correlation between serum anticardiolipin and serum progesterone .11.6%had appositive anticardiolipin case study while 1.2% in control group.