Abstract:
Diabetes mellitus is a major health problem that results in significant
morbidity and mortility from divers complication. Thrombohemorrhagic
complications are well recognized among diabetic population. A total of 100
diabetic type II subjects aged between 30 to 80 years attending Diabetic and
Endocrine Hospital were collected for the study, 20 age and sex matched non
diabetic healthy person were recruited as controls. Prothrombin times (PT),
activated partial thromboplastin time (APTT) and fibrinogen level were estimated
using coagulometer. There were no significant changes in mean PT value (14.17
sec) in result when compared to the controls (mean 14.14 sec) (P=0.92), and no
significant correlation between PT and age of the patients (P=0.236) and duration
of the disease (P=0.132). APTT showed an increase in mean (27.16 sec) when
compared to the mean of controls (25.95 sec), but statistically not significant
(P=0.189). There were insignificant positive correlation between APTT and age of
the patients (P=0.176) and duration of the disease (P=0.385). The mean fibrinogen
level was significantly higher in the diabetic type II patients (mean 358.78 mg/dl)
than the controls (mean 205 mg/dl) (P=0.00).Fibrinogen increased in a time
dependant way and its statistically significant when compared to the age of the
patients (P=0.030), and the duration of the disease (P=0.038). In conclusion we
found that there were no clinical effects of diabetic to the PT value and its rising
APTT value but the value remain in normal limit. Diabetes type II rising plasma
fibrinogen level and it’s affected by duration of the disease and age of the patients.
