Abstract:
This is a cross-sectional study conducted during the period from March to
August 2010, to asses the serum levels of cardiac enzymes (Creatine kinase,
aspartate aminotransferase and lactate dehydrogenase) in 70 Sudanese
patients with type 2 diabetes mellitus in reference to their body mass index
(38 obese and 32 non-obese) as a study group compared with 30 apparently
healthy subjects (non-diabetic, non-obese) as a control group. Participants in
this study were from different hospitals and health centers in Khartoum
state, Sudan. Age and gender of the study group were matched with the
control group. The serum levels of cardiac markers: CK, AST and LDH
were measured using BTS 305 spectrophotometer and commercial kits from
.Biosystem Company
The mean of the serum levels of total Creatinine kinase of the diabetic and
diabetic obese groups were significantly raised (P. value= 0.043) and
(P=0.021), respectively, whereas, they were insignificantly changed in
.diabetic non-obese group when compared to that of the control group
The mean of the serum levels of Aspartate aminotransferase level of all
diabetic group were insignificantly changed when compared to that of the
.(control group (P= 0.141
The mean of serum levels of lactate dehydrogenase of the diabetic and
diabetic obese groups were significantly raised (P=0.045) and (P=0.029),
respectively, whereas, they were insignificantly changed in diabetic non-
.(obese group when compared to that of the control group (P=0.180
In the diabetic group the serum levels of Creatine kinase, Aspartate
transferase and lactate dehydrogenase levels showed insignificant weak
positive correlation with both, the duration of the diabetes mellitus and the
.body mass index of the patients
