Abstract:
A prospective study conducted during the period . July
2004 to April 2005 , 65 people was examined for serum
cholesterol level ( 45 Renal transplant recipients patients versus, 25
control group )
The renal transplant recipients all of them under follow
up at Dr. Salma center for kidney dialysis and transplant.
A sample of blood from each was taken , the specimens
were analyzed for serum cholesterol and whole blood cyclosporine
concentration for study group , while only serum cholesterol level
for control group , The results obtained shows that there was
significant difference between the serum cholesterol in study
group and control group .
(204+38.21 to 155.4+15.68, p<.000 )
The study group divided into three sub groups according
to duration post renal transplantation ( subgroup (A),
< 12
months ) ,( subgroup (B) 12 - 24 months ) , ( subgroup (C) >25
months ). Statistically significant negative correlation was seen
between duration after renal transplantation and serum cholesterol
level
To study the correlation between the cyclosporine
concentration and serum cholesterol level patients group divided
into three subgroups according to cyclosporine concentration
(subgroup (L) <150 ng/ml ) subgroup (M) 150 - 225 ng/ml ),
(subgroup(H)>226 ng/ml ) . The results obtained and statistically
shows no significant correlation between cyclosporine
concentration and serum cholesterol level .
The finding of this study shows that serum cholesterol is
maximal in the first year post renal transplantation (subgroup(A) )
and decreased gradually through the duration
post renal
transplantation , but still higher than that in control group .A person with serum cholesterol level(240 mg/dl and
above ) has more than twice the risk of heart disease than the
others below (240 mg/dl ). In this study 17.5% of patients have
. serum cholesterol >240 mg/dl , and 82.5% below 240mg/dl
