Abstract:
This is descriptive analytical study carried out in the River Nile
state , in the period from (May 2012 to july 2012) to evaluate
some coagulation parameter
among Sudanese children
infected with schistosomiasis. seventy five children were
selected ,59(78%) ofthem were male and 16(22%)female and
twenty five healthy individuals were selected as control group .
4.5 ml of venous blood were drown from each child , placed in
tri sodium citrate container , then centrifuge to get platelets
poor plasma (ppp) and to assess PT , APTT,
fibrinogen and
D.dimer ,The data were analyzed by using statistical package
for social sciences (SPSS) versionl 11.5 , and express as means
. The results show that the means of PT(prothrombin
time),16sec,APPT(activate
partial
thromboplastin
time)34sec,fibrinogen level was 342mg/dl and D-dimer level
was 231ng/l respectively . The mean of PT,APTT, Fibrinogen
and D.dimer in control group were found to be 13sec, 32sec,
286 mg/dl,
192ng/l respectively . The results showed no
significant differences between the means of PT of patients
and controls , but
demonstrated a significant differences
between the mean of patients and controls (APTT) , fibrinogen
level and D.dimer of patient and control (p.value <0.05).
The result obtained indicated that measurement of PT
was
unnecessary when evaluating schistosomiasis patients whom
there was clinical evidence of hemostatic abnormality . The
results of this study raised the possibility of APTT , fibrinogen
level and D.dimer to be used in identifying risk group of
schistosomiasis patients who were likely to develop thrombotic
events.
