Abstract:
This study was carried out in Khartoum Teaching Hospital (KTH)
during the period from November 2008 to March 2009. The main aim of this
study was to determine the sensitivity and resistance patterns of
Pseudomonas aeruginosa isolated from clinical specimens against
gentamicin, carbenicillin and ciprofloxacin. 50 isolates of Ps.
aeruginosa were recovered from wound, urine and ears at the rates of 21
(42%), 23 (46%) and 6 (12%) respectively, indicated that the wounds were
common sites for pseudomonal infections. These isolates were subjected to
in vitro sensitivity testing using the Kirby-Bauer disc diffusion technique.
The age of patients examined were subdivided into five age groups.
Carbenicillin was shown to be the most effective drug (80% sensitivity),
while gentamicin was the least effective agent (34% resistance), followed by
ciprofloxacin (28% resistance). However, while 6% of the Ps. aeruginosa
isolates were resistant to all antimicrobial drug used in this
study (multi-drug resistance), all Ps. aeruginosa isolates from wound
infections were shown to be 100% susceptible to carbenicillin. The age
group 16-30 years (30%) was found to be more exposed group to
pseudomonal infections, while age group 41-60 years (8%) was found to be
the less exposed one.
In conclusion, while most of the Ps. aeruginosa isolates were from
wound infections, carbenicillin was show to be the drug of choice. The
results of sensitivity testing of Pseudomonas clinical isolates indicate that
multi-drug resistance is a major clinical problem that needs further in-depth
study to be resolved.
