Measurement of Fibrinogen Level, Platelet Count and Mean Platelet Volume of Diabetic Patient with Retinopathy

Abstract

This is an analytical descriptive study which carried out in the City of Khartoum at Fedail Hospital in the period from June 2013 to October 2013 to measure the fibrinogen level, platelets count and the mean platelet volume on the diabetic patient with retinopathy. 50 diabetic patients were selected,50 diabetic patients with retinopathy and 50 non diabetic as control group.5 ml of venous blood was drawn from each patient and was divided into 2.5 ml in a Trisodum citrate container then centrifuged to get the platelet poor citrated plasma to measure the fibrinogen level. Stogo coagulation analyzer used to measure the fibrinogen level .The remaining 2.5 ml in EDTA container to measure the platelet count and the mean platelet volume, Sysmex KX21 auto analyzer used to measure the platelet count and the mean platelet volume. The results were obtained and the mean of each parameter was calculated they were as followed: For diabetic patients Fibrinogen level: 300 mg/dl, compared to 371mg/dl for diabetic patients with retinopathy and 278mg/dl for the control group. Platelet count for diabetic patients: 282.000/ml, compared to 237.000/ml for diabetic patients with retinopathy and 255.000/ml for the control group. Mean platelet volume for diabetic patients 10.2 fl , 11.2 for diabetic patients with retinopathy and 10.1 for the control group. This study showed that there is an increase in the fibrinogen level in patients with diabetes and retinopathy when compared to the control group , which indicates the existence of a significant relation between high fibrinogen level and an increased risk of having retinopathy for patients with diabetes type II. This study also showed no significant relation between platelet count and the retinopathy, while there was an increase in the mean platelet volume in patients with retinopathy, which indicated the existence of a significant relation between mean platelet volume and diabetic retinopathy.