Abstract:
This is a cross-sectional descriptive and analytical study,
conducted at Khartoum Teaching Hospital during the period from
February to June 2011.The aim of this study was to assess the
haemostatic parameters (Platelets count, Prothrombin time (PT);
International
normalized
ratio
(INR),
activated
partial
thromboplastine time (A PTT) and Fibrinogen level) in healthy
Sudanese pregnant women who attended Khartoum Teaching
Hospital (obstetric ward).One hundred and thirty samples (130)
were collected from hundred (100) Sudanese pregnant women,
and thirty (30) non pregnant women (control). The participants
were informed about the study and agreed for participation. The
study population was divided into three groups according to
month of pregnancy : first,second and third trimester .Five ml of
venous blood were taken from each subject 2.5 ml in EDTA
containers for platelets count ,and 2.5 ml in tri sodium citrate
containers these were tested for PT, INR, APTT and fibrinogen
level..Fully automated hematological analyzer (Sysmex Kx 21 N
was used for platelets count and Sysmex CA500 was used for
analyzing PT, INR, APTT and fibrinogen level). Statistical analysis
showed significant decrease in platelet count mean during
pregnancy (225×103/μL) compared with control (329×103/μL)
p.value (<0.05).Significant decrease (p.value <0.05)was noted
between the APTT mean of pregnant women(30.7 seconds) and
the APTT mean of non pregnant women(34.0 seconds)and there
was also significant mild decrease in PT mean (14.7) with
INR( 1.2) during pregnancy compared to control(15.5 sec) with
INR(1.3) p.value(<0.05).The study was also showed that there
was a significant increase in plasma fibrinogen level in pregnant
women when compared with non pregnant women (mean of
pregnant
fibrinogen(4.3g/l),non
pregnant
mean(2.5g/l)with
p.value(<0.05) and there was a positive correlation between
number of pregnancies before and the level of fibrinogen.
