Lipid Profile and Creatine Kinase Abnormalities in Patients with Subclinical Hypothyroidism

Abstract

This study was carried out with the participant of 81 patients suffering hypothyroid disease. In which 25 were sub clinical hypothyroidism and 56 were overt hypothyroidism. Patients with other serious diseases such as liver and kidney and cardiac diseases were excluded. Other 18 apparently healthy subjects with no signs of thyroid hormone disease were also participated to served as control. Serum total cholesterol, triglycerides, Creatine kinase, LDL- cholesterol and HDL- cholesterol, TSH, T3, T4 were measured in both hypothyroidism patients as well in euthyroid control subjects. The findings of this study revealed that the majority of hypo thyroid patients presented with clear signs and features of hypothyroidism mainly fatigues, tiredness, etc. and all patients presented with average ages between 35 – 36 years, and females are predominated. The study reverled that TSH hormone in general was significantly highly elevated in both hypothyroidisms compared with control. In sub clinical hypothyroidism elevation in TSH level of about 12- fold over control was noticed 15.8 mu / L versus 1.3 mu /L , while in overt hypothyroidism, about 31- fold increased was observed. But for T3 and T4, the situation is differ. There was no remarkable changes in case of T3 in overt hypothyroidism patients and in sub clinical hypothyroidism. But In case of T4, a significant decrease in T4 was found in overt hypothyroid but remained within the normal value in sub clinical hypothyroidism patients. The findings obtained from this study also revealed that total cholesterol and triglycerides were significantly increased over euthyroid control subjects in both hypothyroid patients. Also LDL- cholesterol were either borderline high (136 mg/dl) compared with control in sub clinical hypothyroidism or high (173mg/dl) in overt hypothyroidism. In case of HDL- cholesterol, the levels were slightly reduced in overt hypothyroidism groups compared with control (44.6 mg/dl versus 49.5 mg/dl) but in subclinical hypothyroid HDL remained unchanged in comparison to control (48.3 versus 49.5 mg/dl). CK in overt hypothyroidisms was significantly elevated (145mg/dl versus 59 mg/dl for control) and remained within normal range for subclinical hypothyroidisms.(78 mg/dl versus 59 mg/dl for control ) . In general the results concluded that lipid profile under hypothyroidism was clearly disturbed in which remarkable increase in total cholesterol, triglycerides and LDL- cholesterol was evident in hypothyroid patients and slight decrease in HDL- cholesterol was also seen. Lipid alteration was return to euthyroid state upon T4- thyroxin therapy. The study also may presume that the tendency of LDL- cholesterol for oxidation may justify it observed elevation in hypothyroid patients and antioxidant. 4 – thyroxine replacement therapy was act as antioxidant