Assessment of Serum Creatine Kinase Activity Among Sudanese Patients with Thyroid Disorders in Khartoum state

Abstract

The aim of the study is assess of serum Creatine Kinase level in Sudanese patients with thyroid disease in Khartoum state during the period of April to July 2011. Sixty serum samples were collected from patients with thyroid disease (30 hypothyroidism and 30 hyperthyroidism patients) and 30 apparently healthy individuals matched in their age and sex, their age between (20-45) years (patients groups; males 20% their age between (20-45) years and80% females their age between (20-45) years). Thyroid hormones levels (T3, T4 and TSH) were determined in those subjects with thyroid disorder and in control group by mean of ELISA in the laboratory management, then the catalytical activity of CK were determined by Cobas Integra 400 technique in Khartoum Teaching Hospital. There were significant decrease in T3, T4 in patients with hypothyroidism when compared with control group; T3 (0.46± 0.17 ), T4 (3.56 ± 0.76), and T3 (1.44 ±0.38), T4 (9.03 ± 2.07 ), and increase in TSH (9.85±7.14), (2.46±0.77), p.value (.000), (.000), (.000) for hypothyroidism patients and control group respectively. There were significant increase in T 3, T4 in patients with hyperthyroidism when compared with control group; T3 (6.27 ±1.9), T4 (19.2±2.9), and T3 (1.44 ±0.38), T4 (9.03 ±2.07), and decrease in TSH (0.146±0.043), (2.64±0.77), p.value (.000), (.000) , (.000) for hyperthyroidism patients and control group respectively. There was statistically significantly elevation in serum Creatine Kinase in patients with hypothyroidism when compared with control group (169.3+23.4) U/L for hypothyroidism patients and (113.9+14.12) U/L for control p.value (.000), also there was a statistically significant decrease in CK levels in patients with hyperthyroidism when compared with Control subject; (88.5+19.6) U/L and (113.9+14.12) U/L), p.value (.000) respectively. In patients with hypothyroidism There was significant negative correlation between serum total T3 and serum total CK (r = -0.852),(P.value 0.00), also between T4 and serum total CK (r= - 0.491, P.value 0.01). There was significant positive correlation between TSH and serum total CK in patients with hypothyroidism (r = 0.581), (P.value 0.00). There was significant negative correlation between serum total T 3 and serum total CK in patients with hyperthyroidism (r = - 0.556), (p.value 0.00), also significant negative correlation with T4(r = -0.448), (p.value 0.01). There was significant positive correlation between TSH and serum total CK in patients with hyperthyroidism (r =0.432, p =0.00). In conclusion the hypothyroidism caused elevation in the total CK level while hyperthyroidism caused decreased in the total CK level.