Abstract:
This case control, hospital base study carried out in tuberculosis
department Port-Sudan teaching hospital red sea state, during the
period from December 2008 to August 2009. The main objectives were
to evaluate the association between tuberculosis infection and lung
cancer using cytological techniques, and to compare the cytological
appearance of sputum using different method of stains (Papanicolaou ,
may-Grunwald and Giemsa , haematoxylin and eosin stain). Sputum
specimens were 200 samples collected from patient complaining from
signs and symptoms of T.B infection and Z.N positive, this group
constitute the case 100 sample, control group 100 sample were Z.N
negative patient with symptoms of chest infection, The results obtained
indicated tuberculosis causes change on the cells we found many
cytological changes among case group ranged from metaplastic change
8%, micro nuclear change 64%, and chronic inflammatory changes28%.
The quality of stains was as follows Papanicolaou stain scored the best
result compare to the May-Grunwald Giemsa stain, and Harris’s
Haematoxylin and Eosin, we conclude that according to our finding there
was no malignant changes on sputum cytology among tuberculosis
patients, we found many metaplastic change which is a pre malignant
status the quality of Papanicolaou stain as method for sputum cytology
is superior to other cytological stains May – Grunwald Giemsa gives
acceptable results. The study recommended to screen T.B patient for
cytological abnormalities and to conduct other study with larger sample
size to confirm or refute our finding.
