Abstract:
This is a descriptive analytical study carried out in Khartoum state during
the period of March 20120 to June 2012 ,to evaluate hemosatic
mechanism among Sudanese women with recurrent miscarriages.Fifty
females with diagnosed miscarriages (three or more) were selected, and
thirty healthy women were selected as control group. 4.5 ml of venous
blood withdrown from each women, placed in tri sodium citrate
container, then centrifuged to get platelets poor plasma (PPP) to measure
prothrombin time (PT), activated thromboplastin time (APTT), thrombin
time (TT) and D-dimer. The results were analyzed by SPSS version 11.5
and express as means, The results obtained showed that the means of
PT(15.8),APTT (36.1),TT(15.6) and D-dimer(787) respectively. The
mean of PT,PTT, TT, and D-dimer of control group was(13.1sec), (31.4
sec), (14.5 sec), and (209 ng/ml) respectively. The results showed
significant differences between the mean value of patients and controls
in prothrombin time PT (P.value <0.05), activated partial thromboplastin
time APTT (P.value <0.05), thrombin time TT (P.value <0.05) and Ddimer
(P.value <0.05). The result show insignificant differences between
age groups, trimesters of miscarriages of case. The results obtain
indicated that measurement of prothrombin time(PT), activated partial
thromboplastin time (APTT)and thrombin time (TT) were necessary
when evaluating female with recurrent miscarriages there was clinical
evidence of hemostatic abnormality.The results of this study confirmed
that the D-dimer test could be use as early predictive marker for further
miscarriages due to hemostatic abnormalities.
