Abstract:
This study was carried out in Khartoum Hospital during the period from
April to July 2012,this study aimed to evaluate the quality of cytological
smear and Cell block technique in the diagnosis of thyroid disorders.
Thirty specimens were collected from patients with thyroid lesions, from
each specimen two smears and cell block were prepared, one stained by Pap
stain ( fixed immediately) and the other stained by May Grun Wald Giemsa
stain(air dried). While cell block was processed and stained with
hematoxylin and eosin, all slides were examined microscopically under light
microscope.
This study revealed that thyroid diseases increase with advanced ages
particularly malignant disorders and affect females 27 (90%) more than
males 3(10%), and the two malignant cases were females (6.7%) . Most
cases were diagnosed as non-neoplastc conditions 28(93.3%) mainly colloid
goiter 26(86.6%).
According to staining quality, Papanicolaou stain showed the best staining
results compare to May Grun Wald Giemsa stain in evaluation of thyroid
disorders. In which 8(26.6%) were evaluated as excellent,7(23.3%) very
good,15(50%) good and no weak results were observed, while in MGG
majority of smears were evaluated as good staining results 19(63.3%)
4(13.3) very good, 7(23.3%) weak and no excellent staining results were
seen.Also this study found that statistically no difference of Pap smear and cell
block techniques. Although excellent staining results were evaluated in
Papanicolauo stain 8(26.6%) more than cell block 3(10%).
Papanicolauo smears were evaluated 7(23.3%) v.good results and 15(50%)
good. While cell block were evaluated 9(30%) v.good results, 18(60%) good
with no weak results in both.
Depend on these findings, study concluded that Pap stain is the best
technique for rapid and early diagnosis of thyroid disorders. Cell block and
Pap smears may be use as complementry technique to each other.
