Abstract:
This is a descriptive analytical study carried out in Khartoum state in the
period of May 2012, to evaluate hemostatic mechanism among Sudanese
multigravida pregnant women in third trimester. Fifty multigravida pregnant
women in third trimester were selected, and twenty five healthy females non
pregnant were selected as control group. Five and half ml of venous blood
was drown from each patient and placed in tri sodium citrate container, then
centrifuged to get platelets poor plasma (PPP) and that is to asses
prothrombin time (PT), activated
partial thromboplastin time (APTT),
Fibrinogen level and D.dimer. The results were analyzed by SPSS version
11.5 and express as mean values the results obtained from cases that the
means of PT (14.1sec), APTT (37.5 sec), Fibrinogen (571mg/dl) and
D.dimer (1167ng/ml) respectively. The mean of PT, APTT, Fibrinogen and
D.dimer in control group were (12.8sec), (31.3 sec), (205mg/dl) and
(291ng/dl) respectively. The results showed significant increase between the
mean of cases and controls in prothrombin time PT (P value <0.05),
activated partial thromboplastin time APTT (P value <0.05), Fibrinogen (P
value <0.05) and D.dimer (P value <0.05). The result show insignificant
differences between age groups, month of the third trimesters and number of
pregnancies. The results obtained indicated that measurement of
prothrombin time (PT), Activated partial thromboplastin time (APTT),
Fibrinogen and D.dimer were necessary when evaluating multigravida
pregnant women, whom there was clinical evidence of hemostatic
abnormality.
