Fibrinogen as Arisk Factor in Cardiovascular Diseases

Abstract

Plasma fibrinogen, total cholesterol triglycerides, TroponinT and cardiac enzymes were measured in control and 53 patients admitted CCU at Elain Governmental Hospital (MAE) suffering acute chest pain and suspected as having myocardial infarction. The patients admitted the hospital at .varying times of chest pain attack The results obtained from this study revealed that 67% of patients admitted the CCU of Elain Hospital were diagnosed as ECG positive, and 58% were elderly. The study also showed that 38% the chest pain patients were hypertensive, and 55% were diabetics. It also pointed out that the chest pain attack was at early morning in about 63%, and 37% of patents had the attack during the evening and most of them presented with severe stress and physical and emotional conditions. The study also demonstrated that about 46% of chest pain patients were heavily smokers, and the majority of them 72% did not claimed family history of MI disease, and 77% of then claimed that no incidence of sudden death in their families were occurred. .Obesity was found in about 69% of the chest pain patients Fibrinogen concentration in control as well as chest pain patients were measured as soon CCU, admission after 10 – 12 hours following the chest pain attack and after 24 hours of chest pain attack. Three levels of plasma fibrinogen concentration were obtained, high value, e.g. about 5.85 g/dL were found after 6 hours of chest pain attack in about 46% of patents, borderline value e.g. 3.43 g/L in about 30% of the patients, and lower value e.g. 2.24 g/L in about 24% of patients theses levels were persisted up to 24 hours of CCU admission before it then start to decline after 24 hours to give values of 4.37 g/L as high value in about 11% of patients, 2.87 g/L as middle value in about 56% of the patients, and 1.72 g/L in as low value in about 33% of .patients It noticeable that the increase in plasma fibrinogen was .correlated with increased plasma viscosity Total cholesterol and triglycerides were also found to elevated to a significant level when compared with control in chest pain patients. Triglycerides were highly elevated than total .cholesterol The activity of all cardiac enzymes (LDH, AST, CK, CK- MB) and tropaninT were significantly raised in which CK-M, .CK, and TroponinT were more elevated