Abstract:
In the present study synthesis of several chalcones and their cyclization reactions
with some reagents (thiourea and thiosemicarbazide) was dealt with, some
heterocyclic aromatic and non aromatic compounds (pyrimidines, thiazines and 2-
pyrazolines) were prepared. Twenty four chalcones were prepared by using
Claisen-Schmidt aldol condensation reaction between some aromatic aldehydes
and methyl ketones (aromatic and aliphatic).The synthesized chalcones on reaction
with thiourea under reflux form pyrimidine derivatives (twenty compounds) and on
reaction with thiourea with stirring under room temperature gave twenty thiazine
derivatives. Some synthesized chalcones were reacted with thiosemicarbazide to
form five- membered ring heterocyclic compound,2-pyrazoline derivatives
(eighteen compounds). The reaction progress for all synthesized compounds was
checked by (TLC) techniques. The structures of synthesized compounds were
confirmed spectroscopically using IR, 1H-NMR and MS.
Synthetic designing and mechanisms of the reactions of the different groups of
compounds were discussed.
