Abstract:
This is a descriptive analytical study carried out in Khartoum
state during the period of March 2012 to July 2012, to
evaluate some haemostatic parameters among lives
diseases patient .Fifty samples with diagnosed liver disease,
were selected, and twenty five healthy individual were
selected as control group The study population were liver
disease patients that include two gall cholecytitis(4 %) ,six
obstructive jaundice (12%) , eleven liver cirrhosis (22.0%) ,
eighteen HBV(36%) , eleven HCV (22%) , and two liver
metastasis (4%). The gender distribution were females 33
(44.7 %), and males 42 (55.3%). The marital status among
the study population was married46 (60.5%) and single 29
(39.5%). , 2.5 ml of venous blood withdrawn from each
patient and control, placed in trisodium citrate container,
then centrifuged to obtain platelets poor plasma (PPP)for
measuring Prothrombin time (PT), activated thromboplastin
time (APTT), thrombin time (TT) and fibrinogen level. .The
compare mean of liver diseases each alone include that
PT of cirrhosis ,jaundice ,HBV ,HCV, Gallcholecytitis, and
liver metastasis are (20.0sec)
The results were analyzed
by SPSS version 11.5 and express as means; the results
obtained showed that the means of PT (17.0sec), APTT
(40.0sec), TT (19.0sec) and fibrinogen level (262.0mg/dl)
respectively. The mean of PT, PTT, TT, and fibrinogen level of
control group were (13.0sec), (31.0sec), (13.0sec), and
(222.0mg/dl) respectively. The results showed highly
significant differences between the mean values of
patients in compare to controls in Prothrombin time PT
(P.value <0.05), activated partial thromboplastin time APTT
(P.value <0.05), thrombin time TT (P.value <0.05) and
fibrinogen level (P.value <0.05). The result show
insignificant differences between age groups, sex ,marital
status ,and disease types .
