Abstract:
This is a descriptive analytical case study carried out in Bashair Renal Center,during
the period from )July /2012 to Augusts /2012) to evaluate PT,APTT and Fibrinogen
among Sudanese chronic failure patient, 35 patients were selected, 27 (77%) males
and 8 (23 %) females , 15 healthy individuals were selected as control group .2.5 ml
of venous blood
was drown from each patient, placed
in
tri sodium citrate
container , was centrifuged to get platelets poor plasma (PPP) .PT,APTT and
Fibrinogen levels were determined by coagulameter, the data were analyzed using
statistical package for social sciences (SPSS) version 11.5. The results obtained from
patients showed that the means of PT (prothrombin time) (17.1sec), APPT (activate
partial thromboplastin time) (43.8sec), and fibrinogen (449mg/dl) . The mean of PT,
APTT and Fibrinogen in control group, (15.4sec), (36.98sec), (320 mg/dl)
respectively . The results showed no significant differences between the mean of
patients and controls in the (PT) (p.value>0.05), also results demonstrated no
significant differences between the mean of activated partial thromboplastin time
(APTT) of patients and controls (p.value>0.05) .Fibrinogen level significantly
increased in case group (p.value < 0.05).
The results obtained indicated that measurement of prothrombin time (PT), activated
partial thromboplastin time (APTT) is important when evaluating chronic renal failure
patients whom there was no clinical evidence of hemostatic abnormality . Fibrinogen
level need to be followed up.
