Abstract:
This is a descriptive cross sectional study which was carried out to
determine
some
immunological
parameters
(anti-cyclic
citrullinated peptide anti-ccp and rheumatoid factor RF ) and
some hematological parameters ( complete blood count and
erythrocyte sedimentation rate ) in patients with rheumatoid
arthritis in Khartoum teaching hospital in the period from January
to May 2011.
For this study the total of ninety four rheumatoid arthritis patient
samples ( n=94 ) have been used in this study , and ninety four
samples (n=94 ) from normal control individuals were tested for
anti-cyclic citrullinated peptides by ELISA, rheumatoid factor ,
complete blood count by Sysmex and erythrocyte sedimentation
rate which can be divided as follows : fifty samples were tested
for anti-ccp alongside with their fifty normal control individuals
and forty four RA samples were tested for ESR ,CBC and RF along
with their normal control individuals. The results showed that all
the patients with rheumatoid arthritis ( 100% ) were positive for
anti-cyclic citrullinated peptides compared to normal control
individuals, And forty two rheumatoid arthritis patients were
positive for rheumatoid factor latex test and two were
negative.Also in the present study the results of forty four
patients of rheumatoid arthritis show a slight decrease in the
hemoglobin concentration mean Hb (12.1 g/dl ±1.5 SD), red blood
cells count mean RBCs (4.5×10^12/L±0.4SD) and packed cell
volume mean PCV (37.9% ±4.0 SD) compared to normal control
individuals and there were ten patients had their hemoglobin
below the normal range or anemic mean Hb ( 10.1g/dl),and some
with lymphopenia mean lymphocyte count (22.7%) as one of the
extra-articular
complication of rheumatoid arthritis and the
erythrocyte sedimentation rate was markedly (P.value=0.00)
elevated mean ESR (57.4 mm/ 1hr ± 34.8 SD) in RA. Also female
(76.59 %) were found to be predominantly more affected than
male (23.15%) .
