Abstract:
Diabetic patients are at a high risk of developing micro and macro vascular diseases. Mean
platelet volume (MPV) and platelet distribution width (PDW) are indicators of platelet
function and activity and they have been reported to be influenced significantly by diabetes.
These changes may have a role in the genesis of diabetic vascular disease.
The present study aims to measure the changes in platelets count, MPV, PDW and P-LCR in
patients with type2 diabetes mellitus.
The study was conducted at Ibrahim Shams Alden Hospital in Khartoum North on 60 patients
of both sexes with type2 DM. Platelet count and platelets indices that are mean platelet
volume (MPV), platelet distribution width (PDW) and platelet large cell ratio (P-LCR) were
measured using an automated blood cell counter. The value of these tests was compared to
matched control group of 40 non-diabetic subjects.
Diabetics registered significantly higher (P≤0.01) values than non-diabetics for MPV
(10.26±1.0 vs. 9.12±0.7fL), PDW (13.83±4.0 vs. 11.84±1.6fL), P-LCR (27.49±7.6 vs.
19.87±4.7%) and lower values for platelets count (244.88±78.3 vs.262.27±63.0) (x10/L)
respectively. No significant variations were observed in the studied indices with respect to
sex or duration of the disease. Platelet indices are significantly affected by type2 DM. Their
clinical utility and association with disease activity in patients with DM should be further
investigated.
