Abstract:
A descriptive cross-sectional hospital based study was conducted in
the Radiation & Isotopes Centre Khartoum (RICK), during the period
from March to August 2013. In order to estimate Vitamin D and
phosphate levels in Sudanese patients with breast cancer,
sixty histologically confirmed breast cancer patients and
thirty apparently healthy females as control group.
Vitamin D was estimated using Euroimmun 25-OH vitamin D
competitive ELISA kits, phosphate was estimated using
phosphomolybdic acid method, fully automated analyzer used for
washing and reading processes, spectrophotometer analyzer for
reading of phosphate concentration, questionnaire and results data
obtained were analyzed using (SPSS version 16).
The results showed, that majority of breast cancer patients at age
41-60 which compose 45%. There was decrease in mean of serum
vitamin D level among patients compared with control group
resulting in (P-value=0.000). This study showed that , no significant
increase in mean serum phosphate levels between patients in
comparison with control group (P-value=0.19). The results showed a
decrease in vitamin D levels in postmenopause compared with
premenaupose breast cancer patients (P-value=0.046).
There was no significant decrease in the mean of serum vitamin D
and no significant increase in the mean of serum phosphate level in
breast cancer patients when classified according to their parity,
body mass index and duration of disease, the results showed week
negative correlation between vitamin D and phosphate.
The study concluded that, there was a decrease in vitamin D level
among Sudanese women with breast cancer especially in
menopause women. Vitamin D supplement trail to evaluate if breast
cancer patients in Sudan needs vitamin D supplement and
monitoring to avoid vitaminosis is recommended. study the vitamin
D and phosphate in correlation with breast cancer stages and
metastasis.
