Abstract:
The chemistry of quinazoline family of compounds including their
preparations, reactions, properties together with a review of their most
important biological activities were dealt with in chapter one.
Thirteen final compounds were prepared in this work, together
with their corresponding intermediates. The appropriate retrosynthetic
analysis of the compounds revealed two possible routes for the target
quinazolinones. The first route required a one step direct reaction
between an amide and anthranilic acid, while the second approach
involve a three step reaction. The three step reaction was achieved
through acetylation of anthranilic acid followed by thermal cyclization to
acetanthranil, the latter was then reacted with the desired amine to obtain
the product. The two approaches were tried and result in the formation of
the same products. The reaction course was followed with TLC and the
identity of the products was identified through U.V, I.R, 1H-NMR and
MS.
The retrosynthetic analysis of the compounds was discussed in
chapter three together with suitable mechanisms of each different
reactions. The spectral data were interpretated and discussed in the same
chapter.
The final compounds were found to possess a weak antimicrobial
activity when tested against five microorganisms, Pseudomonas,
Klebsiella, Proteus, Staphylococcus aureus and Eschrichia coli.
