Characterization of Brain for Pediatric Sudanese Seizure Patients Using MRI

Abstract

IV Abstract The study is applied on pediatric Sudanese patients to characterize and provide possible diagnostic information of seizure patient’s brain which in most cases shows normal appearance. With MRI as main tool, a volumetric measurements took place on temporal lobes and cerebral hemispheres. 53 pediatric patients aged from 2-14 years old were diagnosed with suspected temporal lobe epilepsy according to seizure and request of brain MRI received in MRI department. Control group of 15 and diseased group of 38 were studied, underwent epilepsy protocol and T1, T2 and FLAIR images obtained and manual tracing of temporal lobes and cerebral hemispheres executed and area were calculated. Volume measurements and ratios are compared between structures of both diseased and control groups. Most patients were in age from 4-11 years old and showed reduce in volume of temporal lobe and hemisphere than normal. 73.5% of all sample showed RT temporal lobe larger than LT as (28/38) 73.6% of the diseased sample and 73.3% of the control sample (11/15). Temporal lobe and cerebral hemisphere and temporal lobe to hemisphere ratio were all increased with age linearly. The radiologist independently reviewed all the MR images. Evaluation of temporal lobes signal intensity showed that 2 pediatrics demonstrated changes in signal intensity. Results presented in the study are compatible with similar findings in previous studies, showing that volume measurements, ratios and signal intensity changes are associated with seizure patients.