Abstract:
This is a retrospective descriptive study conducted at Khartoum
state, at different hospitals and Sudan University of Science and
Technology during the period between May to October 2007. This
study aimed to detect the expression of p53 oncogene and corpora
amylacea in tissues affected with prostate cancer and benign
prostatic hyperplasia.
44 samples were selected and classified into four categories;
four samples diagnosed as well differentiated adenocacinoma,
eight samples diagnosed as moderate differentiated
adenocarcinoma, twenty two samples diagnosed as poor
differentiated adenocarcinoma, and ten samples diagnosed as
benign prostatic hyperplasia. H&E performed to confirm the
previous diagnosis. TP53 oncogene was identified using
immunohistological method, and avidin biotin technique, corpora
amylacea was identified using periodic acid Schiff's.
This study found that there was association between
expression of p53 oncogene and corpora amylacea with different
pathological condition. Further studies are recommended to
confirm this finding.
