Abstract:
This is retrospective descriptive hospital based study
aimed to detect the of ki67 tumor marker expression
in the diagnosis of prostatic tumors. The study was
conducted in Radio istope center –Khartoum Sudan
during the period from April to August 2013. Thirty
prostate paraffin blocks previously diagnosed as
prostate tumors were collected. Their ages ranged
from 53 to 93 with mean age 70 years. The majority
of cases were above age 60 years 23 (76.7%). One
section of 3μm
in thickness was cut from each block
using rotary microtome. Sections were prepared and
stained for immunohistochemistry using new indirect
method (Dako(code IS 62630).
Out of 20 (66.6%) cases of prostate adenocarcinoma,
10 (33.33%) sections gave positive expression and
the remaining 10 (33.33%) sections gave negative
results for ki67, while in 10 (33.33%) cases of benign
prostatic hyperplasia 2(6.7%) sections gave positive
and 8(26.6%) sections gave negative results for
ki67 . With no significant relation between ki67
expression and tumor behavior. In conclusion no association between the expression of ki67 and
.behavior of prostate tumor
