Abstract:
A descriptive cross-sectional study was conducted in the Radiation &
Isotopes Centre Khartoum (RICK), Khartoum state, the aim of the present
study is to evaluate serum vitamin D and HDL-C Levels in Breast Cancer
Sudanese Women.
A sixty women with breast cancer and thirty healthy volunteers’ women
as a control group. In this study the test group was composed of 37% in
age between 20-40 (n= 18), 45% in age between 41-60 (n= 29) and 18%
in age more than 60 (n= 13). Immunochemistry ELISA was used for
measurement of Vitamin D, precipitation spectrophotometeric assay was
used for HDL-C estimation, BMI calculated using international formula,
then data were analyzed by Statistical (SPSS version 16) computer
software.
The study results showed a significant decrease in the mean of vitamin D
level in patients compared with control group (P-value 0.00). HDL-C
indicated significant increase patients in compared with control group (P-
value 0.000). There is a significant elevation of the plasma vitamin D
level in premenopausal with breast cancer compared with menopausal
female (P-value 0.04).
In the current study there is insignificant differences reported with all risk
factors used parity, BMI, and duration of disease when compared with
both vitamin D and HDL levels.
The study showed a positive correlation between vitamin D and HDL-C
with (r= +0.025).
In conclusion, there is strong evidence supporting our hypothesis that
vitamin D decreased in breast cancer patients.
