Abstract:
Background: Prolactin is a 198-amino acid protein (23-kD) produced in the
lactotrophs cells of the anterior pituitary gland. Hyperprolactinemia is a condition
of elevated serum prolactin level (Reference Range 78 – 455 mlU/L). It is the most
common hypothalamo-pitiutary disorder, it can also occur secondary to use of
some drugs, chronic illnesses like hypothyroidism, chronic liver and kidney
disease, stress and neurogenic disorders. Idiopathic Hyperprolactinemia refers to
elevation of serum Prolactin in the absence of the above conditions. Primary
infertility is a case of failing to conceive for at least 12 monthes after gotten
marriage.
Objective: The aim of this study is to evaluate serum Prolactin hormone level
among female with primary infertility.
Method: Serum Prolactin, FSH and LH levels were estimated using commercially
specific enzymeimmunoassay (EIA) technique in serum from 200 women (150
primary infertile and 50 fertile non-pregnant and non-lactating) attending Wad
Medani teaching hospital in Wad Medani city, Central Sudan, from 2011 till 2013.
Results: Hyperprolactinemia represent 50 (33.3%) out of 150 (100%) infertile
women. Mean of PRL level was (428.9 mlU/L), Std. Deviation was (361.8)
and P. value was (0.000) Age groups; (16 - 30) was 76 (50.7%) and
(31 - 45) was 74 (49.3%). Regular menstrual cycle was 50 (33.3%) and irregular
menstrual cycle 100 (66.7) Oligomenorrhea was 89 (59.3%) and Amenorrhea was
10 (6.7%). Women with galactorrhoea were 5 (3.3% ) and women whom without
galactorrhea were 145 (96.7%). Correlation between PRL, FSH and LH was highly
significant increase (P=0.000, 0.001 and 0.000) respectively.
Conclusion: One-third of female probability value (P. value)e who
participate in this study had high level of Prolactin, the main aetiology of primary
infertility.
