Abstract:
A descriptive, case-control study conducted in Radiation isotopes center - Khartoum,
during the period from May to October 2008, the study group were obtained from those
living in Khartoum state.
Analytical and statistical methods were applied to estimate the levels of Creatine
kinase and Lactate dehydrogenase enzymes in women with breast cancer under different
types of treatment including mastectomy, chemotherapy, and radiotherapy.
A total of (63) women – both case and control subjects – were studied, their
ages were between 35 to 65 years, in which (33) women were the test subjects,
including (11) with mastectomy, (11) receiving chemotherapy, and (11) with
radiotherapy. 30 healthy women were the control subjects, and their ages were
between 35 to 65 years.
Blood samples from each subject were taken, serum specimens were analyzed
specterophotometricaly for CK and LDH activities. The results were statistically
analyzed.
The results obtained showed that, there was insignificant difference between the
means of serum CK levels, among the test group compared to the control group,
with a P value of 0.252, and a high significant difference between the means of
serum LDH activity, among the test group compared to the control group with a P
value of 0.000.
The ANOVA test results showed that, there was insignificant difference between
the means of serum CK levels with a P value of 0.406, 0.847 and 0.569 among the
test groups mastectomy, chemotherapy, and radiotherapy respectively compared to
the control group, and no increase in enzyme level.
The test also showed that, there was significant difference between the means of
serum LDH activity, among the mastectomy, chemotherapy, and radiotherapy
groups with a P value of 0.019, 0.002 and 0.004 compared to the control group.
This study concluded that, in women with breast cancer under treatment, the
level of total CK was normal because the enzyme predominates mainly in muscle
tissues and breast contain adipose tissues, but there was an increase in LDH level,
and this attributable to anaerobic glycolysis in cancer cells.
