Comparison between C - reactive protein and Total Cholesterol as Markers for Cardiovascular Diseases in Some Sudanese Patients with Type 2 Diabetes Mellitus

Abstract

Diabetes mellitus is a metabolic disorder characterized by hyperglycemia, that can either result from genetic disorders or from defects in insulin .hormone This study is performed in Khartoum state during the period from January .2011 to May 2011 The aim of the study is to compare the sensitivity of C – reactive protein and cholesterol in detection of early cardiovascular disorders in Sudanese .with type2 diabetes mellitus Seventy five blood samples were collected from Sudanese diabetic patient with type 2 diabetes mellitus, their age range from 30 – 60 years, and seventy five healthy volunteers as control group for the comparison. Serum cholesterol was estimated enzymatically with spectrophotometer (Biosystem 310), and CRP level was estimated turbidmetrically with .(automation technique (Mindary BS 300 The study observed significant increase in the C-reactive protein level in the study group of type 2 diabetes mellitus when compared with control group (4.56 ± 1.51 mg/L) verses (1.57 ± 0.33 mg/L) respectively, (P = 0.00), and the level of CRP is greater in females than in males test group of type 2 diabetes mellitus (5.7 ± 1.58 mg/L) verses (4.1 ± 1.45 mg/L) respectively. Significant maximum elevation of C-reactive protein level was observed during the early period of type 2 diabetes mellitus in group 2( from 1 year to 5 years) (5.2 ± 1.56 mg/L). In contrast, cholesterol level reached the maximum level in group 2 (after 20 years from the onset of type 2 diabetes mellitus). The study observed that there is no significant correlation between CRP level and duration of type 2 .diabetes mellitus in the study group In conclusion: CRP is higher in test group of type 2 diabetes mellitus than in healthy individuals, reached the peak maximum in the first five ‫‪level reached the peak maximum after twenty years from the onset of‬‬ ‫‪.type 2 diabetes mellitus‬‬