Estimation of Platelets Count, Platelets Indices, Coagulation Profile and D-dimer among Sudanese Patients with Type 2 Diabetes Mellitus in Khartoum State 2022

Abstract

Diabetic patients are suffering from complication that with long term could lead to death; one of the important complications is hematological changes. This is an analytical case control study that aimed to evaluate platelet count, platelet indices, coagulation profile and D-dimer in type 2 diabetic patients. This study is conducted on 50 diabetic patients and 50 controls in Khartoum state in period between August to October 2022. One hundred (100) venous blood samples were collected in EDTA anticoagulant and Sodium citrate anticoagulant tubes, blood samples were analyzed by Mission HA-360 3-Diff Automatic hematology analyzer, COARTON IM and BIOTIME instruments. Data obtained were analyzed statistically by SPSS version 16 using independent T test and One-way ANOVA test. The results showed that platelet large cell ratio (P-LCR) was significantly increased in diabetic patients compared with control (18.69±6.90(and (14.90±4.42) (p value=0.03), Plateletcrit (PCT) also showed differences in case (0.28±0.08) in compare with control (0.26±0.06) with (p value = 0.04). And D-dimer also revealed significant change when compared with control group (0.50±0.05 vs 0.01±0.06) with p value=0.00. But there were no significant differences in platelet count, MPV, PDW, P-LCC, PT, INR and APTT when compared the diabetics to non-diabetics, with p values (0.22, 0.72, 0.43, 0.94, 0.46, 0.06 and 0.29) respectively. Its concluded from the study that the variation in P-LCR, PCT and D-dimer between diabetic patients and non-diabetic indicate there was variation in platelet size, platelet volume and the ability to formation the thrombus that mean they are large and activated platelet which can cause thrombosis.