Assessment of Plasma Glucose and Lipid Profile in children with Chronic Renal Failure Patients

Abstract

Background: Renal failure (RF) have been recognized as significant medical problems, and also associated with metabolic syndrome. Objectives: The objective of this study was to assess plasma lipid profile and glucose level among CRF children patients in Khartoum state. Methodology: This analytical case control hospital based study include 100 subjects 50 were diagnosed with chronic renal failure and 50 was healthy controls, with matched age and sex, the age ranged from 8to 17 years with their mean 12.3 years. Plasma lipid profile and glucose level were measured using fully Automated Chemistry Analyzer (Mindary BS 200). The data were analyzed using SPSS version (21). Results: The (mean± SD) of duration of disease and BMI in study population were (2.720±1.98, 17.302±3.46) , and also the (mean± SD) of plasma Total cholesterol, trialyceride and glucose level in CRF patients when compared vs healthy controls was significantly increased and it observed a high significant difference, (p-value: (0.003,0.000,0.000), respectively, whereas plasma LDL-C and HDL-C levels presented statistically insignificant relation at (p-value: 0.231, 0.451) respectively. However, the results showed positive correlation between cholesterol and glucose level, as well as between TG and Duration of the Disease, LDL and Glucose(r = 0.280, p = 0.049) (r = 0.032, p = 0.049) (r = 0.377, p = 0.007) respectively, However, no significant correlation was found between Age, BMI and change in serum lipid profile levels. Conclusion: The present study concluded that, the cholesterol, TG and glucose level of the CRF children are higher than control , while LDL, HDL were insignificantly differs from the control groups, However, no correlation was found between age, BMI and change in serum lipid profile levels.