Diagnostic Value of Serum Procalcitonin and Highly Sensitive C- reactive protein in early detection of bacterial blood Infection

Abstract

Background and aim: Several markers of inflammation and sepsis such procalcitonin (PCT)and hs-C.reactive protein (hs-CRP) are being examined to study their accuracy for the diagnosis of bacterial infections in order to treat properly and effectively. This study aims to explain the diagnostic value of serum Procalcitonin test in comparison with hs-C.reactive protein as diagnostic tools for bacterial infections in blood . Method: Analytical cross-sectional hospital-based study include123participants from International Medical Center hospital (IMC) A large hospital in Jeddah, Saudi Arabia hospital from Jan ,1st 2018 to Dec 31st 2018.whom they entered the hospital with fever, high rate of breathing. hs-CRP and PCT in addition to blood culture had been requested. hs-CRP and PCT were measured immediately by automated Cobas machine, the results obtained was analyzed using SPSS version 23. Results: The results showed that (78.9%) of patients were above the age of 60, males are slightly higher than females. PCT and hs-CRP results have been compared with the Blood Culture’s results, sensitivity of PCT & hs-CRP was 100% while specificity was 98 % & 88% respectively. Receiver Operating Curve (ROC) for PCT; AUC= 0.984 with CI (0.954-1.015), P.value 0.00, while hs-CRP; AUC=0.646, with CI (0.547-745), P- value 0.006, which consider more significant on PCT than CRP Conclusion: Procalcitonin is the best marker for diagnosis of blood bacterial infection than hs-CRP.