Determination of Prothrombin Time, Activated Partial Thromboplastin Time and level of D- Dimer among Sudanese Patients with Diabetes Mellitus

Abstract

This is a case control study carried out in Khartoum state in Yastabshiron hospital, in the period from (October 2017 _ October 2018) to evaluate some coagulation parameters in Sudanese patient with Diabetes mellitus in Khartoum state , 40 diagnosed Diabetic patients were selected 17 (42.5%) male and 23(57.5%) female and 40 healthy individuals were selected as control group, 3 ml of venous blood was withdrawn from each patient, placed in tri sodium citrate container , then centrifuge to get platelet poor plasma (PPP) to measure PT,INR, APTT and D-dimer , The result was analyzed by SPSS version 15 , and express as means, The mean of Prothrombin time, INR, and Activated partial thromboplastin time and D- dimer in patients group were(18.19 sec), (1.36), (37.73 sec) and (992.91 ng /ml) respectively , The means of PT, INR, APTT and D-dimer in control group ,(13.85 sec),(1.03), (32.55 sec) and (16.27 ng / ml) respectively. The result showed that there was significant differences in mean of PT, INR, APTT, and D-Dimer between patients group and control group (P.value < 0.05), There was no significant differences in mean of PT, INR, APTT, and D-Dimer between both group of sex (P. value > 0.05), according to the duration of disease there was no significant differences in PT, INR, APTT, and D-Dimer (P. value > 0.05). The results of this study reveal that measurement of PT, INR, APTT, and D-dimer should be use in identifying risk group of Diabetes Mellitus who are likely to develop thrombotic events.