Determination of the effectr of vitamin D deficiency on hematological parameters in Khartoum state

Abstract

Vitamin D deficiency is a common condition that affects many metabolic activities that may cause a significant abnormalities. Vitamin D deficiency (VDD) is generally associated abnormal hematopoiesis and an outcome of varying degrees. Some studies reported an association between VDD and some hematological and non hematological parameters. Hematopoiesis occurs in the bone marrow and is strictly regulated with the help of various cytokines, hormones, growth factors, and even vitamins to supply for a steady state of the circulating red blood cells (RBC), white blood cells (WBC), and platelets (PLT). Lack or deficiency of any of these regulatory factors can potentially slow down the hematopoietic process and lead to a certain abnormality in the production of any one or more of these three cell lines .This study evaluation the haematological parameters among vitamin D deficiency .A total of 130 Sudanese subjects were enrolled in this study, 65 patients with diagnosed with vitamin D deficient disease and 65 healthy volunteers as a control (43%) of control were males and (56%) were females. (28%) of patients were males and (73%) were females all subjects diagnosed with vitamin D deficiency. Blood samples were collected from all participants in Ethylene Diamine tetra acetic acid (EDTA) anticoagulant container, and analyzed by automated hematological analyzer. Patients’ data was collected from patients’ medical files, and analyzed by statistical package for social sciences (SPSS), version 20.The result showed statically significant association between some hematological parameters among study group significant (decreased of MCH in case group P.value =(0.01). There was statistically significant difference in gender distribution when compared in case and control groups.(P.value=0.04) The study showed significant statistical difference between mean of RBCs and MCHC and VD level in patients (decreased in deficient level). ( P.value =0.03, 0.01 ) Respectively. The result showed no statically significant association other RBCs indices and VD level in patients p.value (0.19, 0.11, 0.5, 0.7) respectively. The result showed no statically significant association between WBCs and differential leucocytes count and vitamin VD level in patients p.value(0.3, o.8, 0.2, 0.5, 0.4) respectivelly. The also showed no statically significant association between platelet count and vitamin D level in patients ( P.value =0.2) . The result showed no statically significant association between VD level and gender of patients. (P. value= 0.1) .The result showed significant statistical difference between mean of MCHC and gender of patients (decreased in VI female), P.value=0.03.The result showed no statically significant association between RBCs and other RBCs indices and gender of patients ( p.v=(0.44, 0.85, 0.72, 0.66, 0.06, 0.03) respectively. The result showed significant statistical difference between mean of neutrophils and gender of patients (decreased in female), (P.value=0.04). The result showed no statically significant association between WBCs and other differential leucocytes count and gender of patients p.value=(0.7, 0.3, 0.4, 0.9) respectively. The result showed no statically significant association between platelet count and gender of patients. (P.value =0.1)